microscopio cabeceras

Rafael  Zardoya San Sebastián


914111328 - 1129




Profesor de investigación del CSIC

Líneas de Investigación / Research Lines

Principales líneas de investigación / Main Research Lines:


Molecular Systematics: Understanding how biological diversity is originated is the central question in Evolutionary Biology. We are interested in determining the amount of genetic variation associated to speciation events and its relationship to morphological and behavioral differentiation. We want to establish robust phylogenetic frameworks onto which discuss morphological and behavioral adaptation, as well as the historical generation of current biogeographical patterns and the assembling of ecosystems. We are currently focused mainly on gastropod systematics but he have studied in the past phylogenetic relationships of controversial groups of fishes, amphibians, and reptiles. We are currently based our phylogenetic inferences on complete mitochondrial genome sequence data but we would like to use in the near future next-generation sequencing technologies.


Molecular Evolution: We are interested in the study of mitochondrial and nuclear sequence variation. Our research in this field includes the evolution of gene families, model selection, positive selection, the causes underlying incorrect phylogenetic inferences, etc. Although our approach is largely empirical, we are developing a strong interest in the theory of evolutionary analysis of amino acid and nucleotide sequences.


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Proyectos en curso / Ongoing Projects:


• Understanding the molecular basis of island radiations: Evolutionary study of conotoxins in marine snails Africonus of Cape Verde using transcriptomics. 2016

• Mitogenomics of main gastropod lineages. 2013

• Molecular phylogeny of gastropod mollusks based on complete mitochondrial genomes. 2010

• Phylogenetic relationships of amphibians using complete mitochondrial genomes and Rag1. 2007

• Genetic characterization of rabbit (Oryctolagus cuniculus) populations at the National Park of Cabañeros and the State Property of Lugar Nuevo. 2005

• Identification of specific microsatellites to characterize genetic variability of endemics species of the Iberian peninsula and Canary Islands. 2004

• Intraspecific genetic structure of bigeye tuna, Thunnus obesus in the Atlantic Ocean. 2003

• Molecular systematics of Iberian opistobranchs (Mollusca: gastropoda). 2003

• Anabantoid (Pisces: Perciformes) intra- and inter-relationships: hypotheses testing using DNA sequence data. 2002

• Fisheries and population structure of Scomber spp. In the Mediterranean and South Iberian Atlantic waters. 2001

• Molecular phylogeny of Central American cichlids (Pisces: Perciformes). 2000

• Genetic characterization and spatial delimitation of insect diversity in the Madrid Community. 2000



Miembros del grupo de investigación / Research Group Members:


Michel Dominguez
Juan Esteban Uribe
Ethienne Kornobis
David Osca


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Últimas publicaciones / Latest Publications:


D. Osca, J. Templado, and R. Zardoya, (2014). The mitochondrial genome of Ifremeria nautilei and the phylogenetic position of the enigmatic deep-sea Abyssochrysoidea (Mollusca: Gastropoda). Gene, 547: 257-266 



D. San Mauro, D.J. Gower, H. Muller, S.P. Loader, R. Zardoya, R.A. Nussbaum, and M. Wilkinson, (2014). Life-history evolution and mitogenomic phylogeny of caecilian amphibians. Molecular Phylogenetics and Evolution, 73: 177-189 



F. Abascal, I. Irisarri and R. Zardoya, (2014). Diversity and evolution of membrane intrinsic proteins. Biochimica et Biophysica Acta (BBA)-General Subjects, 1840: 1468-1481 



A. Agorreta, D. San Mauro, U. Schliewen, J.L. Van Tassell, M. Kovacic, R. Zardoya and L. Ruber, (2013). Molecular phylogenetics of Gobioidei and phylogenetic placement of European gobies. Molecular Phylogenetics and Evolution, 69: 619-633 



O. Rican, L. Pialek, R. Zardoya, I. Doadrio, and J. Zrzavy, (2013). Biogeography of the Mesoamerican Cichlidae (Teleostei: Heroini): colonization through the GAARlandia land bridge and early diversification. Journal of Biogeography, 40: 579-593 



E.G. Gonzalez, and R. Zardoya, (2013). Microsatellite DNA Capture from Enriched Libraries. Microsatellite. Humana Press 



F. Abascal and R. Zardoya, (2013).  Evolutionary analyses of gap junction protein families. Biochimica et Biophysica Acta (BBA)-Biomembranes, 1828: 4-14 



D. San Mauro, D.J. Gower, J.A. Cotton, R. Zardoya, M. Wilkinson, and T. Massingham, (2012). Experimental design in phylogenetics: testing predictions from expected information. Systematic Biology, 61: 661-674 



P.S. Fitze, V. Gonzalez-Jimena, L.M. San-Jose, D. San Mauro, and R. Zardoya, (2012). A new species of sand racer, Psammodromus (Squamata: Lacertidae), from the Western Iberian Peninsula Zootaxa, 3205: 41-52 



I. Irisarri, D. San Mauro, F. Abascal, A. Ohler, M. Vences, and R. Zardoya, (2012). The origin of modern frogs (Neobatrachia) was accompanied by acceleration in mitochondrial and nuclear substitution rates. BMC Genomics, 13: 626 



F. Abascal, D. Posada and R. Zardoya, (2012). The evolution of the mitochondrial genetic code in arthropods revisited. Mitochondrial DNA, 23: 84-91 



F. Abascal and R. Zardoya, (2012). LRRC8 proteins share a common ancestor with pannexins, and may form hexameric channels involved in cell‐cell communication. BioEssays, 34: 551-560 



M.T. Cabria, J.R. Michaux, B.J. Gómez-Moliner, D. Skumatov, T. Maran, P. Fournier, J.L. De Luzuriaga, and R. Zardoya, (2011). Bayesian analysis of hybridization and introgression between the endangered european mink (Mustela lutreola) and the polecat (Mustela putorius). Molecular Ecology, 20: 176-190 



I. Irisarri, M. Vences, D. San Mauro, F. Glaw, and R. Zardoya, (2011). Reversal to air-driven sound production revealed by a molecular phylogeny of tongueless frogs, family Pipidae. BMC Evolutionary Biology, 11: 114 



P.S. Fitze, V. Gonzalez-Jimena, L.M. San-Jose, D. San Mauro, P. Aragon, T. Suarez, and R. Zardoya (2011) Integrative analyses of speciation and divergence inPsammodromus hispanicus (Squamata: Lacertidae). BMC Evolutionary Biology, 11: 347 



R.L. Cunha, J.R. Verdú, J.M. Lobo, and R. Zardoya, (2011). Ancient origin of endemic Iberian earth-boring dung beetles (Geotrupidae). Molecular Phylogenetics and Evolution, 59: 578-586 




Otras publicaciones / Other Publications:


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